Special Topic: Death in Childbirth *long post*

Death during childbirth is an oft-used ploy in fiction. If done convincingly, it can add an intensity of tension, emotion, and tragedy to a story that few other events can, probably because the death of a mother and/or child is one of the most prevalent and deeply-held fears of our species. At the moment of miraculous life-giving, life is suddenly and unexpectedly ripped away.

So why is it that death in childbirth has become such a groaner in most fiction? The childbirth death scenes I have read revolve around the dramatic moment (often melodramatic) where the dying mother gasps out a name for her squalling, healthy infant with her last breath and timely expires. The likelihood of this scenario is so miserably small, not just in our modern society, but in every society across time, that it’s frankly laughable to anyone who understands the birthing process.

But fiction is all about making the improbable seem plausible, so if death in childbirth interests you as a plot line, read on.

The Risks of Childbirth Today

In modern day US, maternal mortality – the measure how many women die during pregnancy, birth, or the postpartum period from problems related to childbearing, is 12.1 women in every hundred thousand. That’s right, 12.1:100,000. Pretty sharp odds against. And remember, that’s any woman who is pregnant, giving birth, or having given birth in the last 42 days. The number of women who actually die during the physical act of giving birth to a baby or soon enough afterward to gasp a name and promptly kick the bucket is minuscule in the extreme.

Non-developing nations, including parts of Africa, have much higher rates of maternal death, as high as 920:100,000 in the last 10 years. Reasons for this include lack of prenatal care, unsanitary conditions, lack of qualified, train professionals to oversee the pregnancy and birth, and poverty. Deaths occur for similar reasons as in developed countries.

What about the past?

Historically, maternal death rates have been higher than they are today. In 1915, the rate for US mothers was just over 600:100,000. Still pretty good odds of mom living through the process.

How does home birth fit into the picture?

That’s a trickier question. The answer is, it depends on who you ask. Studies and papers published by MDs proudly proclaim that home birth is three times more likely to kill babies and mothers than hospital births. Studies done by non-medical affiliated groups and groups with vested interest in home birth show a maternal death rate that is much better than modern hospital births. Studies done in other countries, including studies of US births, report a remarkably low rate of maternal death when home births are attended by trained, licensed midwives. Those figures are consistent with home birth statistics in countries with much lower risks of maternal death than the US, like Sweden and Norway, where most births are attended by midwives and many are conducted in a home setting.

I’ll leave it up to you to decide which to believe.

All research I could find on the subject agrees that unassisted childbirth or ‘free childbirth’ is extremely dangerous to mother and baby, with an exponentially higher risk for both.

Going to give mama the ax anyway? Here’s how.

The biggest killers of women giving birth are blood loss, eclampsia (seizures from very high blood pressure), unsafe purposefully-induced abortion, obstructed labor, and sepsis (aka childbed fever). The graph below indicates the percent of total causes of maternal death worldwide and is provided by the NIH (National Institute of Health) based on data from the WHO (World Health Organization). Unsafe abortion is a topic for another day, but let’s consider the other methods.


Blood loss, is generally going to kill much quicker than infection, for obvious reasons, but the tiny trickle of blood folks seem intent to pass off as ‘bleeding to death’ in childbirth is pretty funny. Pregnant women have a third more blood volume than non-pregnant humans. What’s more, the end of pregnancy is the only time in the human life-span when someone can easily lose 30-40% of their total blood volume without going into shock and probably dying. That means a woman would have to lose liters of blood during the birth and shortly after, not counting the amniotic fluid which can dilute and falsely “pump up the volume” of blood being lost. And that’s just for shock to set in.

Blood loss this significant is usually caused by:

  1. a baby that won’t come out and let the uterus (womb) shrink back to it’s normal size

  2. a uterus that is floppy and unable to contract after the baby and placenta (after-birth) are delivered

  3. the placenta is not expelled after the baby is born

  4. something completely unexpected, extremely rare, and oh-shit worthy happens.

Option 1 and you’d end up with dead mom, dead baby after probably 2 days of unsuccessful labor without a C-section. With C-section technology, this situation would likely not continue longer than 24 hours and they’d both be fine, barring surgical complications.

Option 2 has several quick solutions. Putting the baby to the breast will stimulate the uterus to contract as hormones called oxytocin flood the bloodstream. Oxytocin is a hormone that provides a dual function – contracting the uterus and releasing milk from the breasts. Another potential treatment in a modern setting is a “pit-drip” or an IV infusion of a drug called pitocin, which is a synthetic form of oxytocin. Finally, just giving the stomach a good, deep, firm massage will help get the lazy uterus to do it’s job.

Option 3 can benefit from all the suggestions for Option 2, plus a possible surgery called a D&C, or dilation and curettage, which means the doctor opens up the cervix (part of the womb the baby exits through to the birth canal) and scrapes all the stuff on the inside of the womb out. This can be done with a relatively low level of technology, but using non-sterile instruments is a HUGE risk for infection, and there’s also a slight risk of damaging the cervix to the point that the woman would miscarry any future pregnancies.

Option 4 would depend on why she’s losing blood. Rupture of the uterus, part of the placenta covering the mouth of the uterus and preventing baby from leaving, abruption (where the placenta separates from the woman before the baby leaves the womb), or some other trauma would be best guesses for this factor. They are all pretty rare but usually require emergency c-section and surgery to correct the situation. They may end in hysterectomy (removal of the womb), but with a skilled surgeon on hand they are very survivable. A woman suffering one of these problems prior to modern medicine would probably not survive.

In any case, a modern setting is likely to have such life-savers as IV fluids, blood transfusions, and surgical intervention.

Sepsis, or infection was a big killer prior to the advent of antibiotics. Before the move of birth from the home setting to early hospitals in the last century the rate was still relatively low. Once birth moved to hospitals, with questionable sanitation and physicians who were practicing procedures on cadavers and then delivering babies without gloves or hand-washing, the infection rate soared. It remained high despite attempts to treat birth as “sterile” in the middle of the century. Today, a combination of infection control measures and antibiotics has significantly reduced the number of women who die from infection associated with pregnancy, but it still happens today.

The most common reasons for infection, today and in the past, have been unsanitary environments, non-sterile instruments like forceps or surgical tools, unwashed hands, shaving the pubic area, and prolonged labor that goes longer than 24 hours after the amniotic sac ruptures (“the water breaks”). The solutions for these seem pretty easy for the most part – work clean! Of course, in the era before germ theory and the knowledge that infection was spread by microscopic organisms, physicians didn’t wash hands between patients. Why would they? As for the rupture of membranes, the solution for that is easy, too – deliver the baby. In a modern setting, this can be done by C-section, induction of labor (get it started) using a pit-drip or other medications. In a less tech-oriented society or among women who chose a more “natural” venue for birth, nipple stimulation, walking, certain foods, certain herbs (not recommended in modern times), and even sex can kick labor into gear.

The trouble with infection for the scenario that started this discussion is that it takes time to get septic (infection that is generalized throughout the body), usually 3-4 days before symptoms show up and a quick finale afterwards if they aren’t treated promptly. Symptoms include high fever, chills, muscle aches, and foul-smelling drainage from the birth canal. This can progress to shock (low blood pressure), loss of consciousness, and death.

High Blood Pressure in pregnancy is called pre-eclampsia, which can lead to eclampsia. Eclampsia is life-threatening seizures caused by extremely high blood pressure. Signs of pre-eclampsia include swelling of the hands and face, dizziness, headaches, and changes in vision. The only cure for pre-eclampsia or eclampsia is delivery of the baby, but pre-eclampsia can be treated with medications to reduce blood pressure and medications called anticonvulsants can be used to prevent seizures

Obstructed labor, or the inability to push the baby out, can be caused by the position of the baby – breach (feet or butt down) or transverse (side-lying) are the most common positions that cause this. Other causes include weak contractions by the uterus, a very large baby, a very small pelvis in the mom, or a shoulder dystocia (shoulder gets wedged into position behind the pelvic bones). All of these require some intervention from a trained professional. In the case of a positional problem with the baby, a procedure called ‘external version’ can be done, in which the doctor or midwife uses hands on the outside of the belly to gently push the baby around in the fluid-filled womb until it’s in the right position, which is head-down. External version is sometimes successful, but in most cases a C-section will be performed in modern times, and likewise a C-section is indicated for most other causes.

Again, obstructed labor can be a very dramatic event, both in the modern setting and in the historical/fantasy setting, but without prompt intervention, both mother and baby are likely to die, and with it, mom is not at significant risk, though if prolonged, baby can develop brain damage from lack of oxygen.

Summing it up

As you can see, death in childbirth isn’t quite like the movies and books portray it. It can be just as heart-wrenching and dramatic, though, to have a mom die after several days of exhausting labor or a quick descent into infection. And if you have a near-miss planned, you now have a basis of information on the how, when, and why mom’s die in childbirth. If you want more specific information not provided in this post, email me a question or try the following search terms:

  • Maternal mortality

  • Post-partum infection

  • Placental abruption

  • Placenta previa

  • Shoulder dystocia

  • Cephalopelvic dysproportion

  • Cesarean section

  • Home birth

Posted in infection, Medical Procedure, Pregnancy/Birth | Tagged , , , , | 5 Comments

VISION: Written in Blood

A few years back, before I had this wonderful blog as a place to dump all my writerly nursing advice and medical error pet peeves, I wrote an article for a great little e-zine called Vision: A Resource for Writers. (My first sale for actual cash!)

The article was called Written in Blood, and I think many of you might enjoy a look at it. It addresses some of the common myths and misinformation found in novels and hollywood/TV filmography about blood, bleeding and the human body, including some information about how to describe blood in a sensory fashion – sight, taste, touch, smell.

blood spatter photo

You can find the Written in Blood here: http://fmwriters.com/Visionback/Issue36/writblood.htm

Also, browse through the current edition of Vision here: http://www.lazette.net/vision/ The archives are available at the bottom of the screen and are well worth a look – they are truly a wealth of writing wisdom.

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Alcoholism: Long-term Effects and Withdrawal

So your character has a habit. A bad habit. And of course, writing fiction is all about making the characters day a little more difficult. What better time to go cold turkey off the booze than the middle of an action-filled, intensely stressful plot?

Alcohol consumption can be good for the body, in small regular doses. A glass of red wine a day has been proven to have protective benefits for the heart and contains many cancer-fighting anti-oxidants. A pattern of binge drinking or heavy consumption of alcohol, however, can have major negative impacts on social situation, health, and well-being. Alcohol withdrawal can cause life-threatening problems called DTs, or delirium tremens.

Long-term complications

Most of the long-term complications of alcoholism fall into two categories – damage from the drug itself and damage caused by the exceedingly poor nutritional status of most chronic alcoholics.

Probably the most well-known complication of alcoholism is cirrhosis of the liver. Basically, the liver fills up with scar tissue. Below, you’ll find photos of both a healthy liver and a scarred liver with cirrhosis. Cirrhosis can also be caused by viral infections, including several strains of viral Hepatitis, an infection alcoholics and drug users are particularly prone to get. The healthy liver is on the right.

Other direct complications of alcoholism include withdrawal (DTs), physical dependence, inability to abstain from drinking, tolerance (needing more and more alcohol to get drunk), or are primarily social complications like inability to hold a job, dysfunction of relationships, homelessness.

Indirect complications are sometimes worse for the body than the direct ones. Every system of the body is impacted by excessive alcohol intake. Just a few of the massive list of possibilities are below:

  • Altered brain function, including decreased ability to think and reason
  • Impaired judgment both when drinking and when sober
  • Ulcers of the stomach and intestines, bleeding from the intestines (coffee-grounds appearance to the poop)
  • Extreme malnutrition – alcohol has more calories per gram than sugar and carbohydrate foods (breads, cereals, fruits, vegetables), but none of the protein, vitamins or minerals the body needs to stay strong. Weight is not a predictor of nutritional health.
  • Brittle teeth and bones – I once took care of a fellow in the ICU who broke his neck by falling off a couch onto carpet after a bender and 20 years of hard drinking. He is now quadroplegic (unable to move arms or legs)
  • Bleeding – alcohol “thins” the blood, making blood clotting take longer from cut to clot, so chronic alcoholics bleed longer when cut, bruise easier, and are more prone to strokes and brain bleeding with head traumas

Cold Turkey: Delirium Tremens
Cutting the stuff out? If your character has been an addict for a while or has gone on a major binge (even just one if the blood alcohol level was super-high), they can suffer Delirium Tremens. These very uncomfortable physical signs of withdrawal can last for up to a week after the last drink and can get very suddenly worse. People have died from Delirium Tremens and for very chronic alcoholics or long-term very heavy drinkers, the best place to withdrawal is at an in-patient treatment facility. Symptoms of the DTs are below.

  • Tremors/shakes
  • Agitation, confusion, deep sleep for very long periods (a day or longer), stupor, inability to fully wake up,
  • Delirium – a loss of the ability to determine person, place, time, or situation – the person might not be able to remember what year it is, not recognize family members, not understand where he/she is or why things are happening
  • Hallucinations – seeing, hearing, smelling, feeling physical sensations, or tasting things that aren’t really there
  • Fear, anxiety, restlessness, excitement, nervousness, irritability
  • Very sensitive to light, sound, touch, jumpy
  • Rapid changes of mood, depression
  • Seizures – usually full body large motor jerking (to see a seizure click HERE). Seizures of this type are very rhythmic and often involve eye rolling, teeth grinding, a bluish tinge to the face/lips and severe confusion and tiredness or feeling too heavy to move afterward. Seizures are most common in the first 1-2 days after the last drink
  • Pulsing headaches
  • Loss of appetite, nausea, vomiting, stomach pain
  • Pallor, heart palpitations (feels like your heart is doing cartwheels), chest pain
  • Heavy sweating (especially facial and on the palms)
  • Fever

After the physical withdrawal period, the patient is no longer physically dependent on alcohol, but they may continue to by psychologically addicted. They feel like they need alcohol to function, to escape, or just because. Psychological addiction can be a powerful enemy. Alcoholics Anonymous is a 12-step program to help people cope with alcohol addiction. It works. It also requires one to profess a belief in God or a higher power, which isn’t something everyone can do. Cognitive-behavioral therapy and aversion therapy (where drinking is repeatedly associated with a very noxious stimulation, vomiting for instance) have also show to be very successful.

In severe cases where alcohol addiction has become life-threatening, controversial medications which cause the body to violently react to ANY alcohol consumption have been used. These include Antabuse and Disulfiram. Other medications are available for treatment of alcohol addiction, including anti-depressants and drugs to control cravings.

Recent studies suggest that alcoholics who continue to smoke while attempting to stay sober are more likely to relapse than those who quit smoking and drinking at the same time.

For more information on alcoholism, its symptoms, effects, treatments and complications, see:

As an added disclaimer, if you think you or someone you know has an alcohol addiction, seek professional help. Resources in your community can be found through Alcoholics Anonymous, your physician, the local health department, and at any hospital. Remember, information here is for fiction-writing purposes only.

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Infection: Malaria

I vant to suck your blood!

What better time than Halloween to be thinking about blood suckers. The one you see to the right is Anopheles mosquito, and its bite probably doesn’t even hurt, though it might itch later. 41% of the world’s population lives in the home territory of these little vampires, but the loss of blood isn’t that harmful. What your characters have to be wary of is the VTD – Vampire Transmitted Disease. Anopheles mosquitos are often infected with tiny, microscopic parasites that are the cause of one of the most common parasitic diseases in the world – malaria.

Every year around the world, 350-500 million cases of malaria are diagnosed. This disease is anything but rare.

Malaria is caused by several species of parasites – P. falciparum, P. vivax, P. ovale, and P. malariae. These yummy little microscopic bugs have a powerful hunger for red blood cells. The parasites are injected into the body through the bite of infected mosquitoes. Once injected, they race to the liver and begin to multiply. Victims rarely know they are infested during this stage as the 15-100 parasites build an army 30,000 strong before attacking the choice buffet that is the blood stream.

Once inside the blood cells, the parasites multiply and feed, eventually rupturing the blood cell and causing the symptoms of malaria. Symptoms begin anywhere from 7 to 30 days after the mosquito bite, but can be suppressed up to a year by modern anti-malarial drugs. How fast the symptoms start depends on which species of the parasite are infecting the person, and on the person’s own body. Classical malaria attacks are rarely observed these days, but attacks occur every 2-3 days and last 6-10 hours each. The reason for this timing is that the parasites incubate inside infected red blood cells for 2-3 days before the blood cells rupture. In classical episodes, the victim goes through three distinct stages of illness.

  • The cold stage – shivering, chills
  • The hot stage – headaches, fever, possibly seizures (especially in children), vomiting
  • The sweating stage – sweats, normal temperature, extreme tiredness

In general, a victim can experience any of the following symptoms, in any order: chills, fever, weakness, vomiting, sweats, headaches, nausea, muscle aches and generally feeling under the weather. In cases of infection with P. falciparum jaundice (yellowing of the skin and whites of the eyes) can occur along with enlargement of the liver and fast breathing.

Right. Sounds like a nasty case of the flu. What’s the big deal?

Malaria infection killed nearly a million people in 1995 alone, and accounts for over 10% of all childhood death in developing nations. The strain of parasite, P. falciparum, are much more aggressive than the others and can lead to “severe malaria” in which one or more organ system fails to function. Systems and their symptoms are listed below:

  • Brain infection – abnormal behavior, seizures, decreased ability to remain awake, coma or death
  • Severe anemia leading to extreme tiredness and breathing trouble
  • Respiratory distress (breathing trouble) – flaring of the nose, head bobbing, panting, fast breathing, blue tinge to the fingertips, lips or mouth, the inability to get enough air, passing out, death
  • Longer bleeding times before clotting – this can lead to strokes, bruising, actual bleeding, gut-bleeds (bloody or coffee-ground appearance to the poop), bloody urine, etc..
  • Cardiovascular collapse (failure of the blood stream to hold enough fluid in to meet the body’s needs or failure of the heart to pump blood) – symptoms can include chest pain or difficulty breathing or may mimic shock – low blood pressure, loss of consciousness, rapid heart rate, shaking, cold extremities, sweating, lightheadedness, confusion
  • Low blood sugar (starving the brain) – symptoms include dizziness, hunger, headache, shaking, anxiety, and heart palpitations (feels like your heart’s doing flip-flops in your chest. On this I speak from experience)

Today, treatment with antimalarial agents reduces the severity and duration of malaria infection. A list of drugs used appears below, taken from the Centers for Disease Control website.

chloroquine
sulfadoxine-pyrimethamine (Fansidar®)
mefloquine (Lariam®)
atovaquone-proguanil (Malarone®)
quinine (Best bet for pre-modern settings)
doxycycline
artemisin derivatives (not licensed for use in the United
States, but often found overseas)

One more nasty little surprise, malaria caused by the P. ovale or P. vivix strains can lay dormant for months to years in the liver, eventually re-emerging to cause symptoms all over again.

A pound of prevention

Currently, the gold standard for prevention of malaria is using mosquito netting around beds and cribs to prevent mosquito bites. A multitude of non-profit organizations exist whose mission it is to send mosquito netting to poor and under-served populations in areas where malaria is endemic. Other methods include draining wet areas and eliminating standing water where mosquitoes breed, using pesticides to reduce mosquito populations, and using anti-malaria drugs prophylactically (to prevent infection) for pregnant women and individuals traveling to areas where the infection is endemic (native).

An evolutionary twist

One of the most fascinating phenomenon I studied in nursing school was Sickle Cell Anemia. This disorder is a genetic change to the shape of red blood cells that can cause severe problems and even death in those who are symptomatic. However, the trait for Sickle Cell disease actually conveys a protective factor against malaria infection! Considering that this trait developed in the part of the world where malaria have been endemic for the whole of human history, it’s interesting that a twist of genetic selection could breed a trait to keep people from getting sick.

Despite this protective factor, those who develop full-blown sickling, where many red blood cells actually change shape to resemble a curved sickle (see picture), can have life-long severe pain and complications.

Addendum – you can find a map of the parts of the world where malaria is currently endemic (native) at the World Health Organization’s website, this URL http://www.who.int/malaria/malariaendemiccountries.html.

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Happy Reading!

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